Zweli Mkhize declared 10,107 new cases on Saturday, carrying the count to 503,290, alongside 8,153 passings.
South Africa is the hardest-hit nation on the landmass and records for half of every single detailed disease in Africa.
It additionally has the fifth-most elevated number of cases on the planet after the US, Brazil, Russia, and India.
Scientists have said the genuine number of passings in the nation might be far higher.
South African wellbeing specialists have said the pace of contamination is expanding quickly, with cases right now focused around the capital, Pretoria.
Over 33% of the total of what contaminations have been accounted for in Gauteng - South Africa's money related center point, and an area that has immediately become the focal point of the national episode.
Contaminations are not expected to top for one more month.
Reacting to the new figures, President Cyril Ramaphosa approached residents to stay cautious.
"We need to keep on cooperating to diminish the number of new contaminations. Likewise, with numerous different nations over the world, we have to consistently alter the measures we take to forestall new episodes or to shield our wellbeing framework", he said.
South Africa forced a severe lockdown in April and May that eased back the spread of the coronavirus.
The president attempted to feature the positive as South Africa arrived at its troubling achievement in the fight against coronavirus. He highlighted a recuperation pace of 68% and said the number of passings was "essentially lower than the worldwide normal".
In any case, specialists caution to be careful about insights given the various standards and techniques utilized by various areas - and examinations with African nations where there have low degrees of testing.
Mr. Ramaphosa said the lockdown had kept the wellbeing framework from getting at first overpowered and the suspension of liquor deals had altogether decreased the number of injury cases in emergency clinics
However even with such exacting limitations - it has been required, for instance, to wear face veils out in the open since May - social separating is frequently inconceivable in South Africa's thickly stuffed municipalities, where the infection has rushed to spread throughout the winter season.
The president's remarks about examinations concerning claims of defilement over the obtainment of clinical supplies - some asserted to embroil his associates - maybe underline the essence of the issues confronting the nation's wellbeing framework. "It is unseemly that there are individuals who might be utilizing this wellbeing emergency to unlawfully advance themselves," he said.